Acampa M, et al. - Whether an association between P wave dispersion (PWD) and high-sensitive C-reactive protein (hsCRP) in patients with embolic strokes of undetermined source (ESUS) exists, was investigated in order to highlight a possible role for inflammation in the atrial electric remodelling, that predisposes to atrial fibrillation (AF). Neuroimaging examination, arterial ultrasound examination, echocardiography and electrocardiography (ECG) were performed and P wave dispersion and hsCRP were measured in ESUS patients (91 males, 83 females; mean age 69 ± 13 years). Researchers found a significant positive correlation between hsCRP and PWD. Three-fold higher hsCRP was detected in patients with high PWD vs in patients with normal PWD. The hypothesis that systemic inflammation plays a role in a fraction of patients with ESUS, by increasing AF risk via atrial electric remodelling, was supported by these data.