Chatterjee K, Roy A, Banerjee R, et al. - Given Parkinson disease (PD) involves alpha-synuclein and inflammatory pathology but there is a need to further clarify their association with disease pathogenesis, and therefore, researchers assessed α-synuclein-mediated inflammation in the serum of PD patients as well as its connection with disease severity. They compared serum levels of IL-1β, NLRP3, total and phosphorylated α-synuclein. In PD, significantly raised IL-1β, NLRP3 levels were detected. A linear correlation of NLRP3 with α-synuclein was also identified. A significant rise in the levels of phosphorylated α-synuclein was seen in the later stages of PD. Based on these findings, experts concluded the possible involvement of α-synuclein-NLRP3 mediated inflammation in the pathophysiology of PD. In addition, α-synuclein-NLRP3 mediated inflammation might be a new treatment target in PD.