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Infertility, gravidity, and risk of diabetes among high-risk women in the Diabetes Prevention Program Outcomes Study

Journal of Clinical Endocrinology and Metabolism Jan 24, 2020

Kim C, Younes N, Temprosa M, et al. - Researchers carried out a secondary analysis of Diabetes Prevention Program (DPP) and the DPP Outcomes Study over a 15-year period to identify the extent to which infertility [defined as > 1 year of unsuccessful attempts to conceive] and pregnancy independently raise the risk of diabetes and subclinical atherosclerosis. Women who answered questions about gravidity and infertility at baseline (n = 2,085) were included. Among premenopausal women (n = 1,075), women with pregnancy and infertility history (n = 147) and women with pregnancy history without infertility (n = 736) had a greater risk of diabetes than nulligravid women without infertility (n = 173). Premenopausal nulligravid women with infertility history had a non-significant rise in risk, although the number of these women was small (n = 19). Associations among postmenopausal women (n = 1,010) were not observed. No connections between infertility or pregnancy with coronary artery calcification have been observed.
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