White LD, et al. - Given a poor characterization of adverse impacts of induction opioids on the neonate, researchers determined if it is possible to use induction opioids in caesarean section without adversely influencing the neonate. They identified studies from six databases explored systematically from inception until January 2019. The included studies reported comparisons between induction opioids and placebo in caesarean section. A meta-analysis involving 17 studies (n = 987) was performed. Comparisons included remifentanil 0.5–1 μg/kg or 2–3 μg/kg/h, alfentanil 7.5–10 μg/kg and fentanyl 0.5–1 μg/kg vs placebo. Findings revealed the efficacy of induction opioids as sympatholytic agents. The safety of remifentanil and alfentanil was suggested, with no significant influence on Apgar scores or neonatal airway intervention.