Gaudineau A, Senat MV, Ehlinger V, et al. - Researchers conducted the study for testing the noninferiority of vaginal misoprostol (PGE1) (25 μg) to a slow-release dinoprostone (PGE2) pessary (10 μg) for induction of labor with an unfavorable cervix at term.
 They selected women with labor induced for medical reasons, a Bishop score ≤ 5 at ≥ 36 weeks, and a cephalic-presenting singleton pregnancy with no prior cesarean delivery. The research involved 1,674 randomized women. Although the confidence limit of the difference barely exceeded the noninferiority margin, the noninferiority of 25-μg vaginal misoprostol every four hours to the dinoprostone pessary for CD rates after IOL at term could not be exhibited. Despite the small difference in cesarean rates and the similarity of neonatal and maternal morbidity rates in this large study, the clinical risk-benefit ratio justifies the use of both drugs.