Liberale G, et al. - Considering the emergence of indocyanine green fluorescence-imaging (ICG-FI) as a potential tool for increasing the accuracy of staging of patients with primary colorectal cancer (CRC) through the detection of sentinel lymph nodes (SLNs), researchers presented the results of a systematic review of the available literature in the clinical setting of ex vivo and in vivo ICG-FI for the detection of SLNs in primary colorectal cancer. Outcomes suggested a promising efficacy of ICG-FI in detecting SLNs in the setting of CRC. However, more work is required to clearly define protocols and indications for its use and to test its efficacy in larger patient populations.