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Individual variation in adaptive immune responses and risk of hip fracture—A NOREPOS population‐based cohort study

Journal of Bone and Mineral Research Aug 31, 2020

Dahl J, Holvik K, Heldal E, et al. - This research was sought to evaluate how immune responses relate to risk of hip fracture, we looked at the individual variation in a post‐vaccination skin test response that involves some of the immune pathways that also drive bone loss. Researchers analyzed the vast majority of the Norwegian adult population as part of the compulsory nationwide Norwegian mass tuberculosis screening from 1963 to 1975. Among men with a positive tuberculin skin tests, total hip bone mineral density (BMD) was available for a limited subsample and similarly revealed a non‐significantly reduced BMD. Interestingly, there was no such clear correlation in women. After vaccination, an elevated immune response is correlated with an elevated risk of hip fracture decades later among men, possibly because of elevated immune‐mediated bone loss. 

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