Wijbenga RA, Blaauw FJ, Janus SIM, et al. - Utilizing a single-subject study design, researchers sought to examine the temporal relationship between sleep and agitation in individual nursing home residents with dementia experiencing sleep disturbance and agitation. Three of the five participants had a statistically significant temporal association between sleep and agitation. This proof-of-concept study clearly shows the potential of a single-subject study with time series analysis for identifying individualized etiological models that may aid in developing individualized treatment advice for nursing home residents with dementia. This study methodology may benefit future research on (relationships between) neuropsychiatric symptoms in dementia, such as sleep disturbance and agitation because it deals with differences between individuals.