Corrêa ZM, et al. - Researchers conducted a retrospective descriptive analysis of 880 fine needle aspiration biopsies (FNABs) of a solid intraocular tumor of the posterior ocular segment performed by them, in order to define four indication categories of FNABs of solid intraocular tumors. Further, they sought to describe the differences among the patients, tumors, and results of biopsy in these four indication categories. FNABs were performed in 372 cases (42.3%) as a separate procedure, in 279 (31.7%) at plaque implantation, in 225 (25.6%) post-enucleation, and in 4 (0.4%) post-resection/pre-laser. FNABs were categorized as follows: diagnostic that was performed in 292 (33.2%); confirmatory, performed in 121 (13.8%), investigational, performed in 187 (21.3%); and prognostic, performed in 280 (31.8%). Patients who had a tumor of uncertain pathological type underwent diagnostic FNAB, while patients who had a clinically diagnosed malignant intraocular neoplasm underwent confirmatory FNAB. In contrast, a prognostic FNAB was performed on patients who had an unequivocal primary posterior uveal melanoma clinically, while an investigational biopsy was performed on patients who had an unequivocal or probable malignant intraocular tumor of a specific type. Compared to prognostic FNABs (n=143, 51.1%), diagnostic FNABs were performed transvitreous (n=255, 87.3%) mostly. Findings thereby suggest substantial differences among FNAB cases performed for different indications