Puzo C, Labriola Caroline, Sugarman MA, et al. - Using the National Alzheimer’s Coordinating Center Uniform Data Set, researchers longitudinally explored the connection between white matter hyperintensities and neuropsychological, neuropsychiatric, and functional decline among those with normal cognition. The study sample consisted of 465 candidates. According to findings, accelerated cognitive, neuropsychiatric, and functional decline, independent of traditional risk factors and MRI biomarkers for Alzheimer disease, were linked to higher white matter hyperintensities were linked to in this baseline cognitively normal sample.