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Incremental value of computed tomography perfusion for final infarct prediction in acute ischemic cerebellar stroke

Journal of the American Heart Association Oct 29, 2019

Fabritius MP, Reidler P, Froelich MF, et al. - Researchers used advanced computed tomography (CT) including whole-brain CT perfusion (WB-CTP) to determine the imaging parameters that could predict morphologic outcome in cerebellar stroke patients. Using a consecutive cohort with suspected stroke who had WB-CTP, they selected all individuals with cerebellar WB-CTP perfusion deficits and follow-up-confirmed cerebellar infarction. On noncontrast CT, CT angiography source images, and parametric WB-CTP maps, they determined posterior-circulation-Acute-Stroke-Prognosis-Early-CT-Score (pc-ASPECTS). The eligible patients were 60 in total. In univariate linear regression analysis, they found a significant link of pc-ASPECTS on CT angiography source images and cerebral blood flow deficit volume, with final infarction volume. In a multivariate linear regression model adjusted for age, sex, pc-ASPECTS on noncontrast CT, and CT angiography source images and the National Institutes of Health Stroke Scale score on admission, the link of cerebral blood flow deficit volume was corroborated. Findings revealed that WB-CTP imaging vs noncontrast CT and CT angiography provided prognostic information for morphologic outcome in patients with acute cerebellar stroke.

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