Wittekindt C, et al. - Researchers examined a cohort of consecutively included patients with oropharyngeal squamous cell carcinomas (OPSCC) to determine the link with and incidence of human papillomavirus (HPV) in OPSCC in Giessen from 2000-2017. They compared the findings with regional (Giessen and the federal state of Hesse), national (Germany), and international (US) databases. By regional data, the overall incidence rates of oropharyngeal cancers and the incidence of HPV-associated cancers of the tonsils and oropharynx were shown to have increased significantly: no significant change is reported for other oropharyngeal subsites. In Germany and in the US, the incidence has increased significantly, driven by a rising OPSCC incidence in males in the US and in females in Germany.