Argirion I, Zarins KR, Ruterbusch JJ, et al. - This is the first study evaluating temporal changes in Epstein-Barr virus-related nasopharyngeal carcinoma (NPC) incidence in the United States. From 1973 through 2015, incidence and survival data were obtained from the Surveillance, Epidemiology, and End Results program. Stratified analyses were carried out to evaluate temporal trends in NPC by histological subtype, gender, and race. Four thousand four hundred forty-seven cases of NPC were reported among males and 1,838 were reported among females in the US between 1973 and 2015. Findings suggested that the Epstein-Barr virus-related, differentiated NPC subtype is rising across all sexes and races in the US, with distinct incidence and survival disparities among blacks.