Yokoyama K, et al. - Whether the triglyceride (TG)/high-density lipoprotein (HDL) cholesterol (TG/HDL-C) ratio affords a more useful means for estimating low-density lipoprotein (LDL) particle size vs the serum TG level was investigated. In 649 consecutive patients with one additional risk factor for atherosclerotic cardiovascular disease (ASCVD), the estimation of the LDL-particle size (relative LDL migration) was carried out using polyacrylamide gel electrophoresis. Findings suggested a possible greater utility of serum TG/HDL-C ratio vs the serum TG level for assessing the risk of ASCVD. For ASCVD risk reduction, focusing on changes of the serum TG/HDL-C ratio, along with changes of the serum LDL-C, may be important.