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Increased risk of pelvic fracture after radiotherapy in rectal cancer survivors: A propensity matched study

Cancer Medicine May 24, 2019

Kang YM, et al. - In this retrospective analysis, researchers used the National Health Insurance Research Database of Taiwan to investigate if an increased pelvic fracture risk can be seen in rectal cancer survivors in relation to radiotherapy (RT). They evaluated rectal cancer patients who had curative surgery between 1996 and 2011. They defined pelvic fracture as ICD-9 Codes 808, 805.4-805.7, 806.4-806.7, and 820 (including pelvic, sacrum, lumbar, and femoral neck fracture). They carried out one-to-one matches between the RT and non-RT group by using propensity scores for RT, age, and sex. Overall 32,689 patients were identified, with 7807 (23.9%) who received RT, and a pelvic fracture was suffered by 1616. They found that 2.47 years was the median time to pelvic fracture. According to the findings, rectal cancer survivors, particularly women, who received RT, had an increased risk of pelvic fracture.
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