Laprise C, et al. - In this hospital-based case-control study (conducted in Montreal, Canada), researchers analyzed oral rinse and oral brush specimens to assess the association of oral sex behavior with the risk of oropharyngeal cancers (OPCs) and also to estimate the role of oral human papillomavirus (HPV) infection in this association. They observed an increased risk of OPCs with the onset of oral sex practice at age ≥ 16 years vs those with onset after age 30. This association, however, decreased when limited to those positive for HPV. Overall, the link between oral sex and OPC appeared to be mediated by oral HPV infection.