Murugapppan G, et al. Researchers studied the association between female infertility and risk of incident chronic disease in this retrospective cohort analysis performed using the Optum de-identified Clinformatics Datamart from 2003 to 2016. They identified 64,345 infertile women and compared them with 3,128,345 non-infertile patients seeking routine gynecologic care. Compared with non-infertile patients, infertile patients showed higher tendency to develop diabetes, renal disease, liver disease, cerebrovascular disease, ischemic heart disease, other heart disease, and drug abuse, but significantly less tendency to develop alcohol abuse. After excluding women with PCOS and POI, risk associations were similar. While infertility was associated with a low absolute risk of chronic disease, infertile women had a higher risk of incident chronic disease vs non-infertile women.