Skinner SC, et al. - Researchers conducted this study to determine the prevalence of type 2 diabetes (T2D) complications among Senegalese individuals with sickle-cell trait and T2D vs those with only T2D. Study participants included Senegalese individuals with: SCT and T2D (n=60), T2D only (n=52), SCT only (n=53), and neither T2D nor SCT (control participants; n=56). The investigators compared rates of hypertension, retinopathy, peripheral neuropathy, peripheral artery disease, and impaired renal function as well as arterial stiffness, blood rheology, and concentrations of plasma advanced glycation end products (AGEs) and cytokines between the four groups. According to the multivariable analysis, plasma AGE concentration was significantly related to arterial stiffness. Study results suggested that SCT could potentially increase the risk of the development of T2D-related complications, including retinopathy, nephropathy, and hypertension.