He XW, Shi YH, Liu YS, et al. - In view of the recent emergence of circulating microRNAs (miRNAs) as promising biomarkers for acute ischaemic stroke (AIS), researchers examined the expression profiles of miRNAs in AIS patients receiving intravenous thrombolysis and investigated their associations with the outcome. In this prospective cohort study of a total of 84 AIS patients, who received intravenous thrombolysis, patients with unfavorable outcomes vs patients with favorable outcomes had higher miR-124-3p, miR-125b-5p and miR-192-5p levels. Furthermore, they observed a close association of miR-124-3p and miR-125b-5p with stroke severity. Findings thereby suggest the predictive value of these altered miRNAs for outcome in AIS patients receiving thrombolysis.