Müller G, et al. - Fourteen subjects with Kienböck's disease and a control group of 19 healthy subjects were involved in a prospective case–control study by the researchers to assess the use of dynamic contrast-enhanced (DCE) MR for evaluating perfusion in the lunate bone in subjects with Kienböck's disease and to compare perfusion with histopathology with a focus on bone viability. The radiologist assessed features of the enhancement curves from the DCE-MR examinations, time to peak (TTP), maximum slope (MS), and maximum enhancement (ME). Cases with Kienböck's disease exhibited significantly greater and faster perfusion parameters vs the control group. The mean value of the TTP in subjects was 126.73 sec, in controls 189.79 sec and ME in subjects was 173.55 AU, in controls 28.46 AU, and MS in subjects was 5.04 AU, in controls 1.06 AU. Elevated perfusion was observed in areas of bone formation but also in necrosis when it was compared with histopathology. Areas of normal bone exhibited low perfusion. Hence, in patients with Kienböck's disease, DCE-MRI at 3T could diagnose altered perfusion. However, elevated perfusion could not definitely be utilized as a marker of bone viability.