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Increased mortality among patients with vs without cirrhosis and autoimmune hepatitis

Clinical Gastroenterology and Hepatology Nov 21, 2018

van den Brand FF, et al. - In the Netherlands, researchers calculated mortality in a large national cohort of autoimmune hepatitis (AIH) patients with vs without cirrhosis by analyzing data of 449 patients with established AIH (77% female) from 6 academic and 10 non-academic hospitals. Twenty-nine patients with AIH and primary biliary cholangitis and 35 patients with AIH and primary sclerosing cholangitis (AIH-PSC) were identified. Data on mortality and liver transplantation were assessed from August 1, 2006, and July 31, 2016. Patients with AIH-PSC experienced the greatest increase in mortality in all groups vs the general population. They found increased mortality of cirrhosis patients, but not of patients without cirrhosis, compared with the general Dutch population. In patients with AIH and features of concurrent PSC, survival was significantly reduced.

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