Wang Y, et al. - Considering the recommendation to harvest at least 12 lymph nodes (LNs) during surgery for colorectal cancer to avoid understaging of the disease and the debate about if harvestin from locally advanced rectal cancer (LARC) patients who underwent neoadjuvant chemoradiotherapy (neo-CRT) is needed, researchers investigated how lymph node yield (LNY) influenced prognosis in 495 LARC patients who underwent neo-CRT in 2006-2015. Among these, an LNY of less than 12 was reported for 287 (57.98%) patients. Outcomes indicated an improved survival in correlation to LNY of at least 12 for LARC patients treated with neo-CRT. No better tumor regression was evident in relation to reduced LNY. This implies that the necessity of a sufficiently high LNY remains, especially in those with potentially poor tumor response.