Tagirasa R, et al. - Researchers conducted this pilot study to examine the local expression of P-glycoprotein, an efflux-transport protein with role in multi-drug resistance, in vitreous CD4+ T-cells of patients with non-infectious uveitis (NIU). CD4+ T-cells have been isolated from vitreous and peripheral venous blood samples of NIU patients undergoing therapeutic vitrectomy. According to findings, NIU is linked to higher P-glycoprotein expression and pro-inflammatory state in vitreous than in blood. This facilitates P-glycoprotein inhibition and adjunctive local anti-inflammatory therapy in NIU management.