Scavuzzi BM, et al. - Systemic lupus erythematosus (SLE) patients, enrolled in this study, were examined for nitro-oxidative stress in association with disease activity, immune-inflammatory biomarkers, and adhesion molecules. Findings suggested a role of increased nitro-oxidative stress in the (auto)immune pathophysiology of SLE. Furthermore, it was also identified as a modulator of illness severity and adhesion molecule expression in these patients.