Hu SCS, et al. - In Taiwanese psoriasis patients with and without depression, researchers examined the risk of ischaemic heart disease and cerebrovascular disease. Using the National Health Insurance Research Database, a nationwide population-based retrospective cohort study was conducted. Six hundred four psoriasis patients with depression, who were matched to 2416 psoriasis patients without depression (1:4 ratio), were included. Psoriasis patients with depression had a greater risk of developing incident ischaemic heart disease, cerebrovascular disease, and either ischaemic heart disease or cerebrovascular disease vs psoriasis patients without depression. According to subgroup analysis, a higher risk of incident ischaemic heart disease or cerebrovascular disease was present in age groups 30–100 years, in both males and females, as well as in both lower and higher income categories in psoriasis patients with depression. Overall, the authors concluded that depression is an independent risk factor in patients with psoriasis for incident ischaemic heart disease and cerebrovascular disease. Clinicians, therefore, need to be vigilant about the increased vascular risk in depressed psoriasis patients.