Pabla BS, et al. - Researchers determined the risk of gastric cancer in immigrants from high-incidence regions to low-incidence regions (including Western Europe, Australia, Brazil, Canada, Israel, and the United States) through a systematic review and meta-analysis. From January 1980 to January 2019, MEDLINE and EMBASE databases were explored for studies that identified immigrants from high-incidence regions of gastric cancer, provided clear definitions of immigrant and reference populations, and gave sufficient data to calculate gastric cancer incidence and gastric cancer-related mortality. Thirty-eight cohort studies that met the criteria of inclusion were identified. Based on a comprehensive systematic review and meta-analysis, immigrants from regions with high gastric cancer incidence to low-incidence regions sustain a higher risk of gastric cancer and associated mortality. Assessment of immigrant generation along with other risk factors could help identify populations at high risk for prevention and therapeutic interventions.