Abderrahmani A, et al. - Researchers tested their presumption that DNA methylome of livers from patients with T2D, when compared to livers of individuals with normal plasma glucose levels, can unveil some mechanism of hepatic insulin resistance that could link to non-alcoholic fatty liver disease (NAFLD). Findings suggested that through protein kinase C activity, PDGF-AA secretion further stimulated its own expression and contributed to insulin resistance through decreased expression of both insulin receptor substrate 1 and of the insulin receptor. Restoration of hepatocyte insulin sensitivity could be done with PDGF-AA blocking antibodies, PDGF receptor inhibitors and by metformin opening therapeutic avenues. Hence, insulin resistance was contributed by the increased PDGF-AA signalling in the liver of obese patients with T2D.