Lee MJ, et al. - Using a data-driven method, researchers examined the whole-brain resting-state functional connectivity in patients with chronic migraine (CM). Sixty-two patients [44 episodic migraine (EM) and 18 CM; 18–60 years] who visited the headache clinic of the Samsung Medical Center were prospectively recruited and made to undergo 3 T MRI. If patients did not have a migraine headache at the day and ± 1 days of functional MRI acquisition, they were considered interictal. Outcomes revealed stronger connectivity in the pain matrix in CM patients than EM patients. This suggests a possible role of functional alteration of the pain network in migraine chronification.