He H, Li R, Choi S, et al. - Researchers focused on characterizing the blood proteomic signature of patients with atopic dermatitis (AD) as a function of age, by employing the OLINK high-throughput proteomic assay. Participants were 71 patients suffering from moderate to severe AD from 3 age groups (18-40 years old [n = 26], 41-60 years old [n = 24], and > 60 years old [n = 21]) vs 37 age-matched controls. Measurements of serum inflammatory and cardiovascular risk proteins were obtained. Overall 172 differentially expressed proteins were revealed via a comparison between patients with AD from 3 different age groups vs their respective controls. A consistent rise in T_H2 chemokines (CCL13, CCL17) was observed in patients with AD across all ages, whereas incremental rise with age was seen in T_H1 (CXCL10) and T_H17 (KYNU, CCL20) markers in both patients with AD and healthy people. Findings revealed increased levels of systemic inflammatory markers, including those related to cardiovascular and atherosclerosis risk, in elderly patients with AD, this could offer an explanation of their increased incidence of cardiovascular disease. Cardiovascular disease screening and prevention may be beneficial for older patients with AD.