He H, Li R, Choi S, et al. - Given a link of atopic dermatitis (AD) with increased systemic inflammation and cardiovascular risk, and previous reports suggesting raised inflammatory proteins in the blood of AD patients, researchers intended to define the blood proteomic signature of AD patients as a function of age. Participants were 71 moderate-to-severe AD patients from three age groups (18-40 [n = 26], 41-60 [n = 24], > 60 [n = 21]). They also included 37 age-matched controls for comparison. Across all ages, consistently high Th2 chemokines (CCL13, CCL17) were detected in AD patients, while an incremental rise of Th1 (CXCL10) and Th17 (Kynureninase, CCL20) markers with age was noted in both AD and healthy people. Findings revealed increased levels of systemic inflammatory markers, including those related to cardiovascular (GDF15, Myeloperoxidase, ST2) and atherosclerosis (CCL4, CCL7, SORT1) risk, in elderly AD patients, this may afford an explanation for their heightened incidence of cardiovascular disease. The possible advantage of cardiovascular disease screening and prevention in older AD patients was also suggested.