Miola A, Dal Porto V, Tadmor T, et al. - As suicide is identified as a leading cause of death worldwide, researchers sought to determine the factors linked with suicidality (suicidal ideation/suicidal behavior) as it could aid in improving the understanding concerning the pathophysiological underpinnings of suicide and in improving its prevention. Performing a systematic review (PubMed/PsycInfo/Cochrane databases, up to September 2020), they identified 550 references initially. Of which, 21 observational studies involving 7,682 subjects (7,445 with mood disorders or first-episode psychosis, 237 healthy controls) were included. Findings revealed correlation of CRP with higher suicidality in patients with mental disorders. Individuals with high suicidal ideation, and those with suicide attempt showed higher CRP levels relative to non-suicidal individuals (either patients or healthy controls).