Chihara E, et al. - This comparative cohort study was conducted to evaluate the responses of the superficial peripapillary retinal vessel density (VD) and prelaminar flow index (PLFI) to topical Rho-assisted coiled-coil forming protein kinase (ROCK) inhibitor ripasudil and alpha-2 agonist brimonidine using optical coherence tomography angiography. Authors found that the peripapillary VD in primary open-angle glaucoma and ocular hypertension were enhanced by the topical ROCK inhibitor ripasudil, while the alpha-2 agonist brimonidine did not. The PLFI was seen not to respond to either drug.