Wong IYH, Wong RLM, Chan JCH, et al. - In the present study, the researchers sought to compare four screening strategies for diabetic macular edema (DME). The sample consisted of patients attending diabetic retinopathy screening and received macular optical coherence tomography (OCT), in addition to visual acuity (VA) and fundus photography (FP) assessments, as part of the standard protocol. Two thousand two hundred seventy-seven participants (mean age 62.80 ± 11.75 years, 43.7% male) were enrolled. The current protocol's high false-positive rate creates unnecessary referrals, which are inconvenient for patients and expensive for society. Incorporating universal OCT for screening DME may lessen false-positive outcomes by eightfold, whereas improving sensitivity and long-term cost-effectiveness.