Alwan H, La Rosa S, Kopp PA, et al. - In two Swiss regions, researchers determined the trend of lung and gastroenteropancreatic (GEP) neuroendocrine neoplasm (NENs) incidence as per the latest International Agency for Research on Cancer/World Health Organization classification during a 41‐year time frame. Using the Vaud and Neuchâtel Cancer Registries, all cases of lung and GEP NENs from 1976 to 2016 were analyzed. During this time frame, a rise in the incidence of lung neuroendocrine tumors (NETs) by 3.9%/year in men and 4.9%/year in women was reported. A decline by 2.6%/year in lung neuroendocrine carcinomas (NECs) incidence was noted in men from 1985 to 2016, whereas it was shown to rise by 6%/year in females between 1976 and 1998. For both genders, no significant trend in incidence of GEP NECs was identified. The rise in incidence of GEP NETs is probably due to multifactorial etiologies, while the trends in incidence of lung NECs in men and women mirror changes in smoking prevalence in the population.