Grasso C, et al. - This study was designed to shed light on the pattern and reasons for re-hospitalization (RH) after Mitraclip implantation. RH was not uncommon after Mitraclip implantation and was most frequently attributed to cardiovascular causes. Clinical and echocardiographic predictors of early and late RH could be identified at discharge. Early vs late RH carried a worse prognosis.

• This study included a total of 322 consecutive Mitraclip patients, with data stratified by RH status.
• Researchers identified predictors of early (30-day) and late (30-day to 12-month) RH by performing multivariate analyses.

• During the study period, a total of 89 patients (27.6%) had readmission to hospital and early RH occurred in 27% of them.
• Data showed that the median time from Mitraclip to RH was 99 days, and RH was mostly associated with cardiovascular causes (66.3%).
• The most frequent non-cardiovascular causes included anemia and gastrointestinal bleeding.
• The following were identified as independent predictors of early RH: length of stay ≥3 days during the index procedure (odds ratio [OR] 4.13, 95% confidence interval [CI] 1.32-12.91), reduction of left ventricular ejection fraction ≥5% after Mitraclip implantation (OR 4.88, 9% CI 1.36-18.91) and severe systolic pulmonary artery pressure ≥60 mmHg at discharge (OR 3.72, 95% CI 1.23-11.26).
• Conversely, device failure (OR 4.02; 95% CI 1.22-13.25) and systolic pulmonary artery pressure ≥60 mmHg at discharge (OR 2.34, 95% CI 1.01-5.44) were identified as independent predictors of late RH.
• In addition, survival was significantly worse at 12 months in patients with early RHs as compared to patients with late RH and no-RH (69.3% vs 82.6% vs 86%; p < 0.001).