Inohara T, et al. - Researchers intended to characterize the impact of concomitant peripheral artery disease (PAD) on first and subsequent recurrent ischemic events (cardiovascular death, myocardial infarction, and stroke) after an acute coronary syndrome (ACS) given patients with PAD are at increased risk of ischemic cardiovascular events. They analyzed the combined dataset from 4 randomized trials (PLATO, APPRAISE-2, TRA-CER, and TRILOGY ACS) in ACS for a follow-up length of 1-year. The incidence and type of a second recurrent event were assessed among the survivors of a non-fatal first event. In the post-ACS setting, a significantly higher risk of first and recurrent ischemic events was noted in patients with PAD. The relative frequency of each event type within first and subsequent ischemic events was similar regardless of PAD status at baseline.