Yamamoto T, Mizobata Y, Kawazoe Y, et al. - By performing this retrospective post-hoc study of the DExmedetomidine for Sepsis in Intensive care unit Randomized Evaluation (DESIRE) trial, researchers determined the incidence, risk factors, as well as results for sepsis-associated delirium (SAD) among mechanically ventilated patients. The focus was on 28-day mortality, ventilator-free days, length of ICU stay, self-extubation, and re-intubation. Patients were retrospectively split into 2 groups: delirium group (n = 89) and non-delirium group (n = 98). In terms of 28-day mortality, self-extubation, and re-intubation, the groups did not differ significantly. Findings revealed less number of ventilator-free days as well as a longer length of ICU stay in correlation with SAD. The likely independent risk factors for SAD, among mechanically ventilated patients with sepsis, were suggested to be an emergency surgery, more doses of midazolam, and fentanyl.