Alqahtani F, et al. - Using the National Inpatient Sample, researchers evaluated the incidence, predictors, and outcomes of early (in-hospital) percutaneous coronary intervention (PCI) following coronary artery bypass grafting (CABG) in 554,987 patients who had CABG between January 1, 2003 and December 31, 2014. Comparisons were made between patients who had acute coronary ischemia requiring in-hospital PCI after CABG vs those who did not. PCI was performed in 14,323 cases, the majority (71.4%) being performed within 24 hours of CABG. In patients who underwent PCI, higher unadjusted in-hospital mortality was seen (5.1% vs 2.7%). Even after multiple risk adjustments and sensitivity analyses, the higher mortality numbers endured. The strongest predictors of needing an in-hospital PCI following CABG were nonelective admissions and off-pump CABG. Higher rates of strokes (2.1% vs 1.6%), acute kidney injury (16% vs 12.3%), and infectious complications were observed in those who had post-CABG PCI. Longer hospitalizations and an approximate 50% increase in cost were also noted in relation to post-CABG PCI. Overall, an uncommon incidence of in-hospital post-CABG PCI was reported, but it was related to significantly increased morbidity, mortality, and cost.