Chandiramani R, Chen H, Aoi S, et al. - Among acute coronary syndrome (ACS) patients undergoing percutaneous intervention (PCI), researchers assessed the incidence, predictors as well as the influence of stroke on mortality. In the PROMETHEUS multicenter observational study, overall 19,914 ACS patients received PCI. The Kaplan Meier method was employed to compute the cumulative stroke incidence at 30 days as well as 1 year. The occurrence of stroke within 1 year was reported in 244 patients, with a cumulative incidence of 1.5%. The strongest predictor for post‐PCI stroke was previous cerebrovascular disease, followed by ST‐elevation myocardial infarction (MI) presentation, hypertension, non‐ST‐elevation MI presentation, smoking, female gender, and age. In those who had a stroke vs those who did not, a significantly higher mortality risk was observed. However, attenuation of the link was evident over time with a much larger impact in the first 30 days of its occurrence vs beyond 30 days. Overall, it was not uncommon in ACS patients undergoing PCI to encounter stroke within 1 year. Relative to MI and bleeding, a substantial influence of stroke on mortality was revealed that attenuated rapidly over time.