Osler M, et al. - The incidence of suicidal and violent behavior after initiation of antidepressant medication was investigated in this Danish cohort study. Researchers determined the purchase of antidepressant medication, suicide, suicide attempts, and conviction for violent crime among cohorts of 997,911 conscripts and 95,794 patients with a first-time affective disorder in Danish registries between 1997 through 2015. Antidepressant medication was initiated in 16.5% of conscripts and 73.7% of patients with affective disorders. During the first 28 days after initiation, 3-4 times higher incidence of suicide was observed vs the incidence rates reported in the following year in both cohorts. According to the investigators, this finding likely reflects disease severity and a delay in mood response.