Iwase M, Komorita Y, Ohkuma T, et al. - In Japanese patients with type 2 diabetes, researchers used multivariable adjusted Cox proportional models to prospectively examine the incidence of stroke and its subtypes, risk factors and prognosis. The development of stroke over 5 years was evaluated in 4,875 participants with type 2 diabetes (mean age 65.4 years, male 57%, previous stroke 10%). According to results, the incidence rates per 1,000 person-years were 6.7 for new-onset stroke and 22.7 for recurrent stroke. Age, male, reduced regular physical activity, HbA_1c, diabetic kidney disease, and previous stroke were significantly associated with ischemic stroke. Obesity, reduced regular physical activity, HbA_1c and diabetic kidney disease were significantly linked with lacunar infarction. Atherothrombotic stroke was significantly related to age, reduced intake of dietary fiber, reduced regular physical activity, HbA_1c and previous stroke. Depressive symptom was significantly associated with recurrent stroke. The present study stressed the importance of glycemic control and lifestyle modification, like regular physical exercise, for stroke prevention in patients with type 2 diabetes.