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Incidence of residual neuromuscular blockade in children below 3 years after a single bolus of cisatracurium 0.1 mg/kg- A quality assurance study

Acta Anaesthesiologica Scandinavica Oct 31, 2019

Vested M, et al. - In this study with consecutively enrolled 40 patients ≤ 3 years of age scheduled for cleft lip and palate repair, researchers investigated the proportion of patients with residual block (train-of-four (TOF) ratio < 0.9) upon the end of surgery following a bolus of cisatracurium 0.1 mg/kg. The presence of residual block upon conclusion of surgery in less than 10% of the study population was regarded as good quality. The participants were administered general anaesthesia with either sevoflurane and fentanyl (n = 20) or propofol and remifentanil (n = 20). They applied TOF stimulation via acceleromyography on the tibial nerve. To facilitate tracheal intubation, cisatracurium 0.1 mg/kg was delivered. Findings revealed the presence of residual neuromuscular blockade (TOF ratio < 0.9) in 8 % of the children following the receipt of a single bolus of cisatracurium 0.1 mg/kg but experts could not exclude that the true proportion was around 20%.
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