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Incidence of preeclampsia and other perinatal complications among women with congenital heart diseases: Systematic review and meta‐analysis

Ultrasound in Obstetrics & Gynecology Aug 13, 2020

Martinez‐Portilla RJ, Poon LC, Benitez‐Quintanilla L, et al. - Per recent studies, maternal cardiac maladaptation rather than primary placental insult is possibly associated with preeclampsia (PE) occurrence. As congenital heart disease (CHD) is linked with decreased adaptation to the hemodynamic needs of pregnancy, it is hypothesized that risk of PE would be higher in women with CHD. Researchers here examined the risk of PE in women with CHD via performing a systematic review and meta‐analysis. The meta‐analysis was performed on a total of 33 studies, comprising 40,449 women with CHD and a total of 40,701 completed pregnancies. PE incidence of 3.1% was reported. Findings did not indicate an incidence of PE above the expected baseline in women with CHD. Hence, they do not support the theory of the cardiac origin of PE.

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