Incidence of new-onset diabetes mellitus and association with mortality in childhood solid organ transplant recipients: A population-based study
Nephrology Dialysis Transplantation Mar 10, 2019
Chanchlani R, et al. - In this cohort study, researchers used Ontario health administrative data to compare the incidence of diabetes and the hazard of diabetes (overall and at specific intervals posttransplant) between 1020 children undergoing solid organ (kidney, heart, liver, lung and multiple organ) between 1991 and 2014 vs 7,134,067 healthy non-transplanted children. Among transplanted and non-transplanted children, the estimated incidence rate of diabetes during 56,019,824 person-years of follow-up were 17.8 and 2.5 per 1000 person-years, respectively. Compared with the non-transplanted cohort, a 9-fold higher hazard of diabetes was observed in the transplant cohort. Within first year post-transplant, the risk was the highest and continued to be elevated even at 5 and 10 years of follow-up. A 5-fold higher hazard of developing diabetes was observed among lung and multiple organ recipients vs kidney transplant recipients. A three times higher hazard of death was found among diabetic transplant recipients vs those who did not develop diabetes.
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