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Incidence of maternal peripartum infection: A systematic review and meta-analysis

PLoS Medicine Dec 19, 2019

Woodd SL, Montoya A, Barreix M, et al. - Researchers sought to determine the average global incidence of maternal peripartum infection. Screening 31,528 research articles, 111 articles were included in this systematic review of maternal peripartum infection. The World Health Organization defined maternal peripartum infection as infection of the genital tract and surrounding tissues during labour and up to 42 days after birth. Using meta-analysis to combine the estimates of infection and account for variability between studies, it was noted that among 1,000 women giving birth, nearly 39 women present with chorioamnionitis, 16 women with endometritis, 12 women with wound infection, and 0.5 women with sepsis. They identified considerable variation in estimates of infection between different studies, which could be partly explained by world region, the study design, and the criteria used to determine infection. Findings suggest maternal peripartum infection as a significant complication of childbirth and the necessity of undertaking preventive efforts in light of antimicrobial resistance. Relative to modeled global estimates, there seemed a lower incidence risk, although there were differences in definitions that limited comparability.
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