Déruaz‐Luyet A, et al. - Utilizing US commercial claims, researchers contrasted the incidence of lower extremity amputation (LEA) among patients with type 1 diabetes (T1D) and patients with type 2 diabetes (T2D) with those without diabetes and evaluated the presence of key co‐morbidities and precipitating factors at the time of the LEA. Among the matched cohorts of 120,129 T1D patients and 1.7 million T2D patients, the incidence of LEA in T1D patients was higher than in T2D patients, with the most frequent cases being minor LEAs, mainly toe amputations. The data presented in this work showed a higher incidence of LEA, particularly minor LEA, in T1D and T2D patients vs those without diabetes, with a greater risk in T1D patients compared with T2D patients. Accounting for known and measurable risk factors for LEA decreased the relative risk by almost 50%; minor LEAs and toe amputations were the majority of LEA cases.