Capasso A, et al. - Researchers performed enhanced surveillance of Guillain-Barré Syndrome (GBS) in Latin America and the Caribbean (LAC) following the 2015–2016 Zika virus (ZIKV) epidemic in order to determine, for the first time, the regional incidence of GBS. From nine scientific databases and grey literature, searched from January 1, 1980, to October 1, 2018, they identified 6,586 initial citation; of these 31 were eligible for inclusion. In Latin America, background annual GBS incidence rates (IRs) ranged from 0.40/100,000 in Brazil to 2.12/100,000 in Chile. The Caribbean had the pooled annual IR of 1.64. During the ZIKV epidemic, GBS increased 2.6 (95% CI 2.3–2.9) times, and during chikungunya outbreaks, 1.9 times over background rates. In this work, the information gained regarding the epidemiology of GBS in the LAC region may assist in healthcare system planning and preparedness, particularly during arboviral epidemics.