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Incidence of fractures in patients with T1D — A retrospective study with 4420 patients

Osteoporosis International Feb 27, 2020

Stumpf U, et al. - This study intended to evaluate the incidence of fracture in patients with T1DM. A total of 4,258 adult individuals were included with a T1DM diagnosis documented between January 2000 and December 2015 in 1203 general practices in Germany. Researchers conducted individual matching of T1DM and non-diabetic patients. They applied cox proportional hazard models (dependent variable: incident fracture) to determine the impact of T1DM on fracture incidence, as well as the effect of predefined variables on fracture incidence. The cumulative fracture incidence was 18.4% for T1DM individuals and 9.9% for non-diabetic individuals after 10 years of follow-up. Compared with healthy controls, it was noted that individuals with T1DM have a twofold increased fracture rate. Moreover, fractures were correlated with increased age and high HbA1c values.
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