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Incidence of fractures before and after dialysis initiation

Journal of Bone and Mineral Research Aug 04, 2020

Iseri K, Carrero JJ, Evans M, et al. - This retrospective statistical study utilizing the Swedish Renal Registry was performed to determine the incidence of major fractures prior to and following dialysis start. This study involved 361 cases with primary diagnosis of major fracture, including 196 (54%) of hip fractures. A crude incidence rate of 17/1000 (n = 157) and 24/1000 patient‐years (n = 204) was estimated for major fractures before and after dialysis initiation, respectively. Factors related to raised fracture incidence both prior to as well as after dialysis start were: higher age, female gender, and history of previous major fractures. Experts identified that an increase in the incidence of major fractures, particularly hip fractures, started to occur at 6 months prior to the start of dialysis therapy, suggesting that during the transition period to dialysis, heightened surveillance with execution of preventive measures to prevent fractures is warranted.

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