Haga H, et al. - Hepatocellular carcinoma (HCC) incidence was compared between hepatitis B virus (HBV) genotypes B (HBV/B)- and C (HBV/C)-infected patients. Among 295 hepatitis B surface antigen (HBsAg)-positive carriers, researchers followed a total of 241 patients. Genotypes of HBV were A in 1% (4/295), B in 61% (179/295), C in 37% (110/295) and D in 1% (2/295) patients, and 96% of HBV/B were infected with subgenotype Bj. HBV/B infected patients were diagnosed with HCC at significantly higher mean age than HBV/C infected patients. Compared to patients with HBV/C infection, those with HBV/B had significantly higher value of FIB-4 index. Higher rate of HCC was noted in HBV/C than in HBV/B, and a significant difference was observed until the 20-year observation period. However, thereafter, an increase in HCC associated with HBV/B was observed, and there was no significant difference between HBV/B and HBV/C.